USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages

Mincle is essential for tumor-associated macrophage (TAM)-driven cancer progression and represents a potential immunotherapeutic target for cancer. Nevertheless, the lack of a specific inhibitor has largely limited its clinical translation. Here, we successfully developed a gene therapeutic strategy...

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Detalles Bibliográficos
Autores principales: Xue, Vivian Weiwen, Chung, Jeff Yat-Fai, Tang, Philip Chiu-Tsun, Chan, Alex Siu-Wing, To, Travis Hoi-Wai, Chung, Justin Shing-Yin, Mussal, Francis, Lam, Eric W.-F., Li, Chunjie, To, Ka-Fai, Leung, Kam-Tong, Lan, Hui-Yao, Tang, Patrick Ming-Kuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463747/
https://www.ncbi.nlm.nih.gov/pubmed/34589582
http://dx.doi.org/10.1016/j.omto.2021.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463747/
https://www.ncbi.nlm.nih.gov/pubmed/34589582
http://dx.doi.org/10.1016/j.omto.2021.08.010

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