Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice

Fatal familial insomnia (FFI) is a dominantly inherited prion disease linked to the D178N mutation in the gene encoding the prion protein (PrP). Symptoms, including insomnia, memory loss and motor abnormalities, appear around 50 years of age, leading to death within two years. No treatment is availa...

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Detalles Bibliográficos
Autores principales: Lavigna, Giada, Masone, Antonio, Bouybayoune, Ihssane, Bertani, Ilaria, Lucchetti, Jacopo, Gobbi, Marco, Porcu, Luca, Zordan, Stefano, Rigamonti, Mara, Imeri, Luca, Restelli, Elena, Chiesa, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463834/
https://www.ncbi.nlm.nih.gov/pubmed/34358614
http://dx.doi.org/10.1016/j.nbd.2021.105455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463834/
https://www.ncbi.nlm.nih.gov/pubmed/34358614
http://dx.doi.org/10.1016/j.nbd.2021.105455

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