Disabling de novo DNA methylation in embryonic stem cells allows an illegitimate fate trajectory

Genome remethylation is essential for mammalian development but specific reasons are unclear. Here we examined embryonic stem (ES) cell fate in the absence of de novo DNA methyltransferases. We observed that ES cells deficient for both Dnmt3a and Dnmt3b are rapidly eliminated from chimeras. On furth...

Descripción completa

Detalles Bibliográficos
Autores principales: Kinoshita, Masaki, Li, Meng Amy, Barber, Michael, Mansfield, William, Dietmann, Sabine, Smith, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463881/
https://www.ncbi.nlm.nih.gov/pubmed/34518230
http://dx.doi.org/10.1073/pnas.2109475118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463881/
https://www.ncbi.nlm.nih.gov/pubmed/34518230
http://dx.doi.org/10.1073/pnas.2109475118

Ejemplares similares