TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

NACHT, LRR, and PYD domains–containing protein 3 (NLRP3) inflammasome activation is beneficial during infection and vaccination but, when uncontrolled, is detrimental and contributes to inflammation-driven pathologies. Hence, discovering endogenous mechanisms that regulate NLRP3 activation is import...

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Detalles Bibliográficos
Autores principales: Fischer, Fabian A., Mies, Linda F. M., Nizami, Sohaib, Pantazi, Eirini, Danielli, Sara, Demarco, Benjamin, Ohlmeyer, Michael, Lee, Michelle Sue Jann, Coban, Cevayir, Kagan, Jonathan C., Di Daniel, Elena, Bezbradica, Jelena S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463895/
https://www.ncbi.nlm.nih.gov/pubmed/34518217
http://dx.doi.org/10.1073/pnas.2009309118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463895/
https://www.ncbi.nlm.nih.gov/pubmed/34518217
http://dx.doi.org/10.1073/pnas.2009309118

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