Cargando…

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

NACHT, LRR, and PYD domains–containing protein 3 (NLRP3) inflammasome activation is beneficial during infection and vaccination but, when uncontrolled, is detrimental and contributes to inflammation-driven pathologies. Hence, discovering endogenous mechanisms that regulate NLRP3 activation is import...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fischer, Fabian A., Mies, Linda F. M., Nizami, Sohaib, Pantazi, Eirini, Danielli, Sara, Demarco, Benjamin, Ohlmeyer, Michael, Lee, Michelle Sue Jann, Coban, Cevayir, Kagan, Jonathan C., Di Daniel, Elena, Bezbradica, Jelena S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463895/ https://www.ncbi.nlm.nih.gov/pubmed/34518217 http://dx.doi.org/10.1073/pnas.2009309118

Ejemplares similares

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer
por: Durand, Joel K., et al.
Publicado: (2018)

IKKε and TBK1 expression in gastric cancer
por: Eun Lee, Seung, et al.
Publicado: (2016)

Targeting HER2(+) breast cancer: the TBK1/IKKε axis
por: Jiang, Zhe, et al.
Publicado: (2014)

Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2018)

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
por: Zhao, Peng, et al.
Publicado: (2022)

IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
por: Carr, Matthew, et al.
Publicado: (2020)

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
por: Hutti, Jessica E., et al.
Publicado: (2012)

An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions
por: Reilly, Shannon M., et al.
Publicado: (2013)

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
por: Fang, Run, et al.
Publicado: (2017)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
por: Lafont, Elodie, et al.
Publicado: (2018)

Publisher Correction: Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
por: Xu, Jin, et al.
Publicado: (2019)

SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε
por: Qin, Yue, et al.
Publicado: (2017)

IKKβ is required for the formation of the NLRP3 inflammasome
por: Nanda, Sambit K, et al.
Publicado: (2021)

Functionally Distinct Effects of the C-Terminal Regions of IKKε and TBK1 on Type I IFN Production
por: Nakatsu, Yuichiro, et al.
Publicado: (2014)

Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway
por: Wilcz‐Villega, Ewa, et al.
Publicado: (2020)

Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency
por: Wegner, Julia, et al.
Publicado: (2023)

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
por: Bezbradica, Jelena S, et al.
Publicado: (2017)

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
por: Mowers, Jonathan, et al.
Publicado: (2013)

Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury
por: Córdoba-David, Gina, et al.
Publicado: (2022)

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
por: Ullah, Tomalika R., et al.
Publicado: (2023)

B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
por: Lee, Michelle S.J., et al.
Publicado: (2021)

Epistatic effect of TLR3 and cGAS‐STING‐IKKε‐TBK1‐IFN signaling variants on colorectal cancer risk
por: Catalano, Calogerina, et al.
Publicado: (2019)

A novel TBK1/IKKϵ is involved in immune response and interacts with MyD88 and MAVS in the scallop Chlamys farreri
por: Liu, Wenjuan, et al.
Publicado: (2023)

How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis
por: Demarco, Benjamin, et al.
Publicado: (2022)

The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways
por: Möller, Moritz, et al.
Publicado: (2020)

Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury
por: Rehman, Rida, et al.
Publicado: (2021)

The Kinase MAP4K1 Inhibits Cytosolic RNA-Induced Antiviral Signaling by Promoting Proteasomal Degradation of TBK1/IKKε
por: He, Tian-Sheng, et al.
Publicado: (2021)

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors
por: Nizami, Sohaib, et al.
Publicado: (2020)

Tissue-specific immunopathology during malaria infection
por: Coban, Cevayir, et al.
Publicado: (2018)

The ion channel CALHM6 controls bacterial infection‐induced cellular cross‐talk at the immunological synapse
por: Danielli, Sara, et al.
Publicado: (2023)

MCPIP1 negatively regulate cellular antiviral innate immune responses through DUB and disruption of TRAF3-TBK1-IKKε complex
por: Chen, Xiaojuan, et al.
Publicado: (2018)

Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex
por: Huang, Li, et al.
Publicado: (2017)

IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses
por: Asare, Yaw, et al.
Publicado: (2022)

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor
por: Ozasa, Koji, et al.
Publicado: (2019)

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex
por: Siu, Kam-Leung, et al.
Publicado: (2009)

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study
por: Lork, Marie, et al.
Publicado: (2018)

NKT Cells Join the Two Step for Inflammasome-Independent IL-1β Release
por: Bezbradica, Jelena S., et al.
Publicado: (2020)

PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling
por: McKee, Chloe M., et al.
Publicado: (2021)

Targeting TBK1 Attenuates LPS-Induced NLRP3 Inflammasome Activation by Regulating of mTORC1 Pathways in Trophoblasts
por: Lee, Sohee, et al.
Publicado: (2021)

A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ
por: Wang, Man, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mc2op0j0docfcidbp7p5nn3u6s