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Saturation mutagenesis charts the functional landscape of Salmonella ProQ and reveals a gene regulatory function of its C-terminal domain

The global RNA-binding protein ProQ has emerged as a central player in post-transcriptional regulatory networks in bacteria. While the N-terminal domain (NTD) of ProQ harbors the major RNA-binding activity, the role of the ProQ C-terminal domain (CTD) has remained unclear. Here, we have applied satu...

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Detalles Bibliográficos
Autores principales: Rizvanovic, Alisa, Kjellin, Jonas, Söderbom, Fredrik, Holmqvist, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464044/
https://www.ncbi.nlm.nih.gov/pubmed/34450657
http://dx.doi.org/10.1093/nar/gkab721