HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis

The activity of hematopoietic factor GATA-1 is modulated through p300/CBP-mediated acetylation and FOG-1 mediated indirect interaction with HDAC1/2 containing NuRD complex. Although GATA-1 acetylation is implicated in GATA-1 activation, the role of deacetylation is not studied. Here, we found that t...

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Detalles Bibliográficos
Autores principales: Yan, Bowen, Yang, Jennifer, Kim, Min Young, Luo, Huacheng, Cesari, Nicholas, Yang, Tao, Strouboulis, John, Zhang, Jiwang, Hardison, Ross, Huang, Suming, Qiu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464053/
https://www.ncbi.nlm.nih.gov/pubmed/34450641
http://dx.doi.org/10.1093/nar/gkab737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464053/
https://www.ncbi.nlm.nih.gov/pubmed/34450641
http://dx.doi.org/10.1093/nar/gkab737

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