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HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis
The activity of hematopoietic factor GATA-1 is modulated through p300/CBP-mediated acetylation and FOG-1 mediated indirect interaction with HDAC1/2 containing NuRD complex. Although GATA-1 acetylation is implicated in GATA-1 activation, the role of deacetylation is not studied. Here, we found that t...
Autores principales: | Yan, Bowen, Yang, Jennifer, Kim, Min Young, Luo, Huacheng, Cesari, Nicholas, Yang, Tao, Strouboulis, John, Zhang, Jiwang, Hardison, Ross, Huang, Suming, Qiu, Yi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464053/ https://www.ncbi.nlm.nih.gov/pubmed/34450641 http://dx.doi.org/10.1093/nar/gkab737 |
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