Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

Multiple pathways mediate the repair of DNA double-strand breaks (DSBs), with numerous mechanisms responsible for driving choice between the pathways. Previously, we reported that mutating five putative phosphorylation sites on the non-homologous end joining (NHEJ) factor, Ku70, results in sustained...

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Detalles Bibliográficos
Autores principales: Saha, Janapriya, Bae, Jinsung, Wang, Shih-Ya, Lu, Huiming, Chappell, Lori J, Gopal, Purva, Davis, Anthony J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464062/
https://www.ncbi.nlm.nih.gov/pubmed/34428289
http://dx.doi.org/10.1093/nar/gkab743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464062/
https://www.ncbi.nlm.nih.gov/pubmed/34428289
http://dx.doi.org/10.1093/nar/gkab743

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