NMR solution structures of Runella slithyformis RNA 2′-phosphotransferase Tpt1 provide insights into NAD(+) binding and specificity

Tpt1, an essential component of the fungal and plant tRNA splicing machinery, catalyzes transfer of an internal RNA 2′-PO(4) to NAD(+) yielding RNA 2′-OH and ADP-ribose-1′,2′-cyclic phosphate products. Here, we report NMR structures of the Tpt1 ortholog from the bacterium Runella slithyformis (RslTp...

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Detalles Bibliográficos
Autores principales: Alphonse, Sébastien, Banerjee, Ankan, Dantuluri, Swathi, Shuman, Stewart, Ghose, Ranajeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464070/
https://www.ncbi.nlm.nih.gov/pubmed/33880546
http://dx.doi.org/10.1093/nar/gkab241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464070/
https://www.ncbi.nlm.nih.gov/pubmed/33880546
http://dx.doi.org/10.1093/nar/gkab241

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