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NMR solution structures of Runella slithyformis RNA 2′-phosphotransferase Tpt1 provide insights into NAD(+) binding and specificity
Tpt1, an essential component of the fungal and plant tRNA splicing machinery, catalyzes transfer of an internal RNA 2′-PO(4) to NAD(+) yielding RNA 2′-OH and ADP-ribose-1′,2′-cyclic phosphate products. Here, we report NMR structures of the Tpt1 ortholog from the bacterium Runella slithyformis (RslTp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464070/ https://www.ncbi.nlm.nih.gov/pubmed/33880546 http://dx.doi.org/10.1093/nar/gkab241 |