Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models

Adeno-associated virus (AAV) vector mediated expression of therapeutic monoclonal antibodies is an alternative strategy to traditional vaccination to generate immunity in immunosuppressed or immunosenescent individuals. In this study, we vectorized a human monoclonal antibody (31C2) directed against...

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Detalles Bibliográficos
Autores principales: Rghei, Amira D., van Lieshout, Laura P., McLeod, Benjamin M., Pei, Yanlong, Lopes, Jordyn A., Zielinska, Nicole, Baracuhy, Enzo M., Stevens, Brenna A. Y., Thomas, Sylvia P., Yates, Jacob G. E., Warner, Bryce M., Kobasa, Darwyn, Fausther-Bovendo, Hugues, Kobinger, Gary P., Karimi, Khalil, Thompson, Brad, Bridle, Byram W., Susta, Leonardo, Wootton, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464737/
https://www.ncbi.nlm.nih.gov/pubmed/34572372
http://dx.doi.org/10.3390/biomedicines9091186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464737/
https://www.ncbi.nlm.nih.gov/pubmed/34572372
http://dx.doi.org/10.3390/biomedicines9091186

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