Prediction of Drug–Drug Interaction Potential of Tegoprazan Using Physiologically Based Pharmacokinetic Modeling and Simulation

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model of tegoprazan and to predict the drug–drug interaction (DDI) potential between tegoprazan and cytochrome P450 (CYP) 3A4 perpetrators. The PBPK model of tegoprazan was developed using SimCYP Simulator(®) and verified by...

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Detalles Bibliográficos
Autores principales: Yoon, Deok Yong, Lee, SeungHwan, Jang, In-Jin, Kim, Myeongjoong, Lee, Heechan, Kim, Seokuee, Kim, Bongtae, Song, Geun Seog, Rhee, Su-jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464955/
https://www.ncbi.nlm.nih.gov/pubmed/34575565
http://dx.doi.org/10.3390/pharmaceutics13091489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464955/
https://www.ncbi.nlm.nih.gov/pubmed/34575565
http://dx.doi.org/10.3390/pharmaceutics13091489

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