Cargando…

Induced Pluripotent Stem Cells to Model Juvenile Myelomonocytic Leukemia: New Perspectives for Preclinical Research

Juvenile myelomonocytic leukemia (JMML) is a malignant myeloproliferative disorder arising in infants and young children. The origin of this neoplasm is attributed to an early deregulation of the Ras signaling pathway in multipotent hematopoietic stem/progenitor cells. Since JMML is notoriously refr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wehbe, Zeinab, Ghanjati, Foued, Flotho, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465353/ https://www.ncbi.nlm.nih.gov/pubmed/34571984 http://dx.doi.org/10.3390/cells10092335

Ejemplares similares

Current Treatment of Juvenile Myelomonocytic Leukemia
por: Mayerhofer, Christina, et al.
Publicado: (2021)

Proteomic Analysis of an Induced Pluripotent Stem Cell Model Reveals Strategies to Treat Juvenile Myelomonocytic Leukemia
por: Pearson, Stella, et al.
Publicado: (2019)

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia
por: Fluhr, Silvia, et al.
Publicado: (2016)

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia
por: Stieglitz, Elliot, et al.
Publicado: (2017)

P1000: JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) INHIBITS T CELL PROLIFERATION VIA THE ECTONUCLEOTIDASE CD39 AND THE PURINERGIC NETWORK
por: Rajak, Jovana, et al.
Publicado: (2023)

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia
por: Hofmans, Mattias, et al.
Publicado: (2021)

The Genomic Landscape of Juvenile Myelomonocytic Leukemia
por: Stieglitz, Elliot, et al.
Publicado: (2015)

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia
por: Louka, Eleni, et al.
Publicado: (2021)

Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells
por: Tasian, Sarah K, et al.
Publicado: (2018)

CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out
por: Dal Molin, Anna, et al.
Publicado: (2021)

Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia
por: Liu, Xiaoling, et al.
Publicado: (2012)

Genomic and Epigenomic Landscape of Juvenile Myelomonocytic Leukemia
por: Fiñana, Claudia, et al.
Publicado: (2022)

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia
por: Niemeyer, Charlotte M., et al.
Publicado: (2010)

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
por: Lipka, Daniel B., et al.
Publicado: (2017)

Novel splicing-factor mutations in juvenile myelomonocytic leukemia
por: Takita, J, et al.
Publicado: (2012)

Molecular and phenotypic diversity of CBLmutated juvenile myelomonocytic leukemia
por: Hecht, Anna, et al.
Publicado: (2020)

P1072: NATURAL HISTORY OF JUVENILE MYELOMONOCYTIC LEUKEMIA
por: Yang, W., et al.
Publicado: (2022)

Effect on Multipotency and Phenotypic Transition of Unrestricted Somatic Stem Cells from Human Umbilical Cord Blood after Treatment with Epigenetic Agents
por: Ghanjati, Foued, et al.
Publicado: (2016)

Single-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia
por: Marcu, Andra, et al.
Publicado: (2020)

Clinical and molecular features of CBL-mutated juvenile myelomonocytic leukemia
por: Yoshida, Taro, et al.
Publicado: (2023)

Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs
por: Zhao, Wencheng, et al.
Publicado: (2018)

Deficiency of CREB and over expression of miR-183 in juvenile myelomonocytic leukemia
por: Liu, Y L, et al.
Publicado: (2013)

Management of Two Juvenile Myelomonocytic Leukemia Patients According to Clinical and Genetic Features
por: Tüfekçi, Özlem, et al.
Publicado: (2015)

Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia
por: Sakaguchi, Hirotoshi, et al.
Publicado: (2015)

Juvenile Myelomonocytic Leukemia in Turkey: A Retrospective Analysis of Sixty-five Patients
por: Tüfekçi, Özlem, et al.
Publicado: (2018)

Use of Rapamycin in a Patient With Juvenile Myelomonocytic Leukemia: A Case Report
por: Upadhyay, Shivani Y., et al.
Publicado: (2017)

Parvovirus B19 Infection Mimicking Juvenile Myelomonocytic Leukemia in an Immunocompetent Child
por: Mathew, Aji, et al.
Publicado: (2020)

Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia
por: Kitazawa, Hironobu, et al.
Publicado: (2021)

P985: CLL-1 IS AN ADOPTIVE IMMUNOTHERAPY TARGET IN JUVENILE MYELOMONOCYTIC LEUKEMIA
por: Huebner, Juwita, et al.
Publicado: (2023)

MicroRNA fingerprints in juvenile myelomonocytic leukemia (JMML) identified miR-150-5p as a tumor suppressor and potential target for treatment
por: Leoncini, Pier Paolo, et al.
Publicado: (2016)

S206: ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT
por: Hartmann, Mark, et al.
Publicado: (2023)

Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia
por: Eisenwort, Gregor, et al.
Publicado: (2021)

Prolonged Pediatric Extracorporeal Membrane Oxygenation Support with Cardiopulmonary Failure in Juvenile Myelomonocytic Leukemia
por: Bartkevics, Maris, et al.
Publicado: (2020)

Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples
por: Behnert, Astrid, et al.
Publicado: (2021)

Leukemia cutis in a child with juvenile myelomonocytic leukemia presenting with Sweet syndrome–like lesions and a history of multiple juvenile xanthogranulomas
por: Quek, Chrystie Wan Ning, et al.
Publicado: (2020)

Combination of DNA-hypomethylating agent and hematopoietic stem cell transplantation in treatment of juvenile myelomonocytic leukemia: A case report
por: Ai, Yuan, et al.
Publicado: (2020)

Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation
por: Dvorak, Christopher C., et al.
Publicado: (2014)

Validation of flow cytometric phospho-STAT5 as a diagnostic tool for juvenile myelomonocytic leukemia
por: Hasegawa, D, et al.
Publicado: (2013)

Juvenile myelomonocytic leukemia in the molecular era: a clinician’s guide to diagnosis, risk stratification, and treatment
por: Wintering, Astrid, et al.
Publicado: (2021)

Case Report: Juvenile Myelomonocytic Leukemia Underlying Ornithine Transcarbamylase Deficiency Safely Treated Using Hematopoietic Stem Cell Transplantation
por: Eguchi, Hiroi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4i90n5llv0li19rbphj24im3p6