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Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11
SIMPLE SUMMARY: Chemotherapeutic DNA-damaging agents targeting replication are widely used but predictive rationales for drug combinations and patient selection still need clinical definition. Here, we review cancer-associated replication stress (RepStress) and its genomic signature, and propose how...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465591/ https://www.ncbi.nlm.nih.gov/pubmed/34572827 http://dx.doi.org/10.3390/cancers13184601 |