Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

SIMPLE SUMMARY: Chemotherapeutic DNA-damaging agents targeting replication are widely used but predictive rationales for drug combinations and patient selection still need clinical definition. Here, we review cancer-associated replication stress (RepStress) and its genomic signature, and propose how...

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Detalles Bibliográficos
Autores principales: Jo, Ukhyun, Murai, Yasuhisa, Takebe, Naoko, Thomas, Anish, Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465591/
https://www.ncbi.nlm.nih.gov/pubmed/34572827
http://dx.doi.org/10.3390/cancers13184601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465591/
https://www.ncbi.nlm.nih.gov/pubmed/34572827
http://dx.doi.org/10.3390/cancers13184601

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