Cargando…
A Novel Competitive Binding Screening Assay Reveals Sennoside B as a Potent Natural Product Inhibitor of TNF-α
Natural products (NPs) have played a significant role in drug discovery for diverse diseases, and numerous attempts have been made to discover promising NP inhibitors of tumor necrosis factor α (TNF-α), a major therapeutic target in autoimmune diseases. However, NP inhibitors of TNF-α, which have th...
Autores principales: | Peng, Lei, Durai, Prasannavenkatesh, Park, Keunwan, Pyo, Jeong Joo, Choi, Yongsoo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465676/ https://www.ncbi.nlm.nih.gov/pubmed/34572435 http://dx.doi.org/10.3390/biomedicines9091250 |
Ejemplares similares
-
Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening
por: Durai, Prasannavenkatesh, et al.
Publicado: (2020) -
Machine learning-based chemical binding similarity using evolutionary relationships of target genes
por: Park, Keunwan, et al.
Publicado: (2019) -
Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods
por: Durai, Prasannavenkatesh, et al.
Publicado: (2021) -
Aquaporins Alteration Profiles Revealed Different Actions of Senna, Sennosides, and Sennoside A in Diarrhea-Rats
por: Cao, Yixin, et al.
Publicado: (2018) -
Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E(2) and the Inhibition of H(+)/K(+)-ATPase
por: Hwang, In Young, et al.
Publicado: (2015)