Oxidized LDL Downregulates ABCA1 Expression via MEK/ERK/LXR Pathway in INS-1 Cells

Impaired insulin secretion is one of the main causes of type 2 diabetes. Cholesterol accumulation-induced lipotoxicity contributes to impaired insulin secretion in pancreatic beta cells. However, the detailed mechanism in this process remains unclear. In this study, we proved that oxidized low-densi...

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Detalles Bibliográficos
Autores principales: Lyu, Jingya, Fukunaga, Kensaku, Imachi, Hitomi, Sato, Seisuke, Kobayashi, Toshihiro, Saheki, Takanobu, Ibata, Tomohiro, Yoshimura, Takafumi, Iwama, Hisakazu, Murao, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465850/
https://www.ncbi.nlm.nih.gov/pubmed/34578896
http://dx.doi.org/10.3390/nu13093017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465850/
https://www.ncbi.nlm.nih.gov/pubmed/34578896
http://dx.doi.org/10.3390/nu13093017

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