Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9

Ocular hypertension (OHT) is a serious adverse effect of the widely prescribed glucocorticoid (GC) therapy and, if left undiagnosed, it can lead to glaucoma and complete blindness. Previously, we have shown that the small chemical chaperone, sodium-4-phenylbutyrate (PBA), rescues GC-induced OHT by r...

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Detalles Bibliográficos
Autores principales: Maddineni, Prabhavathi, Kasetti, Ramesh B., Kodati, Bindu, Yacoub, Sam, Zode, Gulab S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465971/
https://www.ncbi.nlm.nih.gov/pubmed/34576258
http://dx.doi.org/10.3390/ijms221810095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465971/
https://www.ncbi.nlm.nih.gov/pubmed/34576258
http://dx.doi.org/10.3390/ijms221810095

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