Cargando…

siRNA-Loaded Hydroxyapatite Nanoparticles for KRAS Gene Silencing in Anti-Pancreatic Cancer Therapy

Pancreatic carcinoma (PC) is greatly induced by the KRAS gene mutation, but effective targeted delivery for gene therapy has not existed. Small interfering ribonucleic acid (siRNA) serves as an advanced therapeutic modality and holds great promise for cancer treatment. However, the development of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Dandan, Xu, Xiaochun, Iqbal, M. Zubair, Zhao, Qingwei, Zhao, Ruibo, Farheen, Jabeen, Zhang, Quan, Zhang, Peiliang, Kong, Xiangdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466089/ https://www.ncbi.nlm.nih.gov/pubmed/34575504 http://dx.doi.org/10.3390/pharmaceutics13091428

Ejemplares similares

Nanomaterial-assisted CRISPR gene-engineering – A hallmark for triple-negative breast cancer therapeutics advancement
por: Farheen, Jabeen, et al.
Publicado: (2022)

Calcium phosphate nanoparticles-based systems for siRNA delivery
por: Xu, Xiaochun, et al.
Publicado: (2016)

Therapeutic siRNA silencing in inflammatory monocytes
por: Leuschner, Florian, et al.
Publicado: (2011)

Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy
por: Wang, Changbing, et al.
Publicado: (2020)

siRNA Versus miRNA as Therapeutics for Gene Silencing
por: Lam, Jenny K W, et al.
Publicado: (2015)

FGFR3 silencing by siRNA inhibits invasion of A549 cells
por: Li, Yuhua, et al.
Publicado: (2016)

Nanocarriers for delivery of siRNA as gene silencing mediator
por: Morales-Becerril, Aideé, et al.
Publicado: (2022)

Multifunctional nanosystems: growing sanguinity in siRNA therapy
por: Badrealam, Khan Farheen, et al.
Publicado: (2014)

Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice
por: Hattori, Yoshiyuki, et al.
Publicado: (2020)

In vivo silencing of alpha-synuclein using naked siRNA
por: Lewis, Jada, et al.
Publicado: (2008)

High potency silencing by single-stranded boranophosphate siRNA
por: Hall, Allison H. S., et al.
Publicado: (2006)

Primary and Secondary siRNAs in Geminivirus-induced Gene Silencing
por: Aregger, Michael, et al.
Publicado: (2012)

Chitosan Hydrogel as siRNA vector for prolonged gene silencing
por: Ma, Zhiwei, et al.
Publicado: (2014)

Strategies for Improving siRNA-Induced Gene Silencing Efficiency
por: Safari, Fatemeh, et al.
Publicado: (2017)

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing
por: Vollmann, Elisabeth H., et al.
Publicado: (2017)

Differences in silencing of mismatched targets by sliced versus diced siRNAs
por: Sun, Guihua, et al.
Publicado: (2018)

RORC2 Gene Silencing in Human Th17 Cells by siRNA: Design and Evaluation of Highly Efficient siRNA
por: Hakemi, Mazdak Ganjalikhani, et al.
Publicado: (2013)

siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
por: Zhang, Chunling, et al.
Publicado: (2006)

GW body disassembly triggered by siRNAs independently of their silencing activity
por: Serman, A., et al.
Publicado: (2007)

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci
por: Shin, Jun-Hye, et al.
Publicado: (2013)

Dendrimers as Carriers for siRNA Delivery and Gene Silencing: A Review
por: Wu, Jiangyu, et al.
Publicado: (2013)

SiRNA silencing efficacy prediction based on a deep architecture
por: Han, Ye, et al.
Publicado: (2018)

Nuclear-targeted siRNA delivery for long-term gene silencing
por: Li, Na, et al.
Publicado: (2017)

siRNA Design to Silence the 3′UTR Region of Zika Virus
por: Perez-Mendez, María, et al.
Publicado: (2020)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
por: Alshehri, Abdullah, et al.
Publicado: (2018)

Silencing of HMGA2 by siRNA Loaded Methotrexate Functionalized Polyamidoamine Dendrimer for Human Breast Cancer Cell Therapy
por: Abedi Gaballu, Fereydoon, et al.
Publicado: (2021)

Engineering siRNA-loaded and RGDfC-targeted selenium nanoparticles for highly efficient silencing of DCBLD2 gene for colorectal cancer treatment
por: Huang, Hongli, et al.
Publicado: (2023)

Effects of siRNA-mediated HIF-1α gene silencing on angiogenesis in osteosarcoma
por: Zhang, Xu-dong, et al.
Publicado: (2017)

Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA
por: Liu, Xiaoxia, et al.
Publicado: (2014)

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing
por: Zhang, Xueli, et al.
Publicado: (2022)

Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake, Gene Silencing and Toxicity
por: Vader, Pieter, et al.
Publicado: (2010)

Designing of Highly Effective Complementary and Mismatch siRNAs for Silencing a Gene
por: Ahmed, Firoz, et al.
Publicado: (2011)

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
por: Vaish, Narendra, et al.
Publicado: (2011)

Design of potential siRNA molecules for hepatitis delta virus gene silencing
por: Singh, Sarita, et al.
Publicado: (2012)

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing
por: Strapps, Walter R., et al.
Publicado: (2010)

Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing
por: Dohmen, Christian, et al.
Publicado: (2012)

Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages
por: Gaglione, Maria, et al.
Publicado: (2014)

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain
por: Rungta, Ravi L, et al.
Publicado: (2013)

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**
por: Jayaraman, Muthusamy, et al.
Publicado: (2012)

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth
por: Khan, Tayeba, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o4ia70lksrcn4imgkn2pbnc4f1