C5a Activates a Pro-Inflammatory Gene Expression Profile in Human Gaucher iPSC-Derived Macrophages

Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic GBA1 mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glycosphingolipid, to glucose and ceramide. GCase defic...

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Detalles Bibliográficos
Autores principales: Serfecz, Jacquelyn C., Saadin, Afsoon, Santiago, Clayton P., Zhang, Yuji, Bentzen, Søren M., Vogel, Stefanie N., Feldman, Ricardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466165/
https://www.ncbi.nlm.nih.gov/pubmed/34576075
http://dx.doi.org/10.3390/ijms22189912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466165/
https://www.ncbi.nlm.nih.gov/pubmed/34576075
http://dx.doi.org/10.3390/ijms22189912

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