Cargando…

NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

Radiation resistance is a significant clinical problem in rectal cancer treatment, the mechanisms of which are poorly understood. NRF2 signalling is known to contribute to chemo/radioresistance in some cancers, but its role in therapeutic resistance in colorectal cancer (CRC) is unexplored. Using si...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Cathail, Séan M., Wu, Chieh-Hsi, Thomas, Rachael, Hawkins, Maria A., Maughan, Tim S., Lewis, Annabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466195/ https://www.ncbi.nlm.nih.gov/pubmed/34573012 http://dx.doi.org/10.3390/antiox10091380

Ejemplares similares

Combining Oncolytic Adenovirus with Radiation—A Paradigm for the Future of Radiosensitization
por: O’Cathail, Sean M., et al.
Publicado: (2017)

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods
por: Rayner, Emily, et al.
Publicado: (2019)

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)
por: O’Cathail, Séan M., et al.
Publicado: (2020)

Neutrophil–lymphocyte ratio is prognostic but not predictive of response to Abiraterone in metastatic castration-resistant prostate cancer
por: Sundar, Santhanam, et al.
Publicado: (2015)

Superior outcomes of nodal metastases compared to visceral sites in oligometastatic colorectal cancer treated with stereotactic ablative radiotherapy
por: O'Cathail, Sean M., et al.
Publicado: (2020)

Stereotactic Body Radiation Therapy Reirradiation for Locally Recurrent Rectal Cancer: Outcomes and Toxicity
por: Smith, Thomas, et al.
Publicado: (2020)

Challenges and Consequences of COVID-19 in the Management of Anorectal Cancer: Coming Together Through Social Distancing
por: O'Cathail, S.M., et al.
Publicado: (2020)

Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea
por: O'Cathail, Sean M., et al.
Publicado: (2023)

Update on Neoadjuvant Regimens for Patients with Operable Oesophageal/Gastrooesophageal Junction Adenocarcinomas and Squamous Cell Carcinomas
por: Cox, Samantha J., et al.
Publicado: (2017)

Stereotactic body radiotherapy for moderately central and ultra-central oligometastatic disease: Initial outcomes
por: Cooke, Rosie, et al.
Publicado: (2020)

The Use of Patient-Facing Teleconsultations in the National Health Service: Scoping Review
por: O'Cathail, Micheal, et al.
Publicado: (2020)

Definitive chemoradiation in patients with inoperable oesophageal carcinoma
por: Crosby, T D L, et al.
Publicado: (2004)

Initial Results from the Royal College of Radiologists' UK National Audit of Anal Cancer Radiotherapy 2015
por: Muirhead, R., et al.
Publicado: (2017)

Use of Teleconsultations in a Regional Stereotactic Radiosurgery Service: Pilot Study
por: O'Cathail, Micheal, et al.
Publicado: (2021)

The in-silico feasibility of dose escalated, hypofractionated radiotherapy for rectal cancer
por: Devlin, Lynsey, et al.
Publicado: (2022)

Therapeutic Potential of Protein Tyrosine Kinase 6 in Colorectal Cancer
por: Jerin, Samanta, et al.
Publicado: (2023)

The Impact of COVID-19 on Radiotherapy Services in Scotland, UK: A Population-based Study
por: Grocutt, L., et al.
Publicado: (2023)

Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
por: Hsu, Wei-Lun, et al.
Publicado: (2022)

ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer
por: Wilson, James M., et al.
Publicado: (2016)

Changes in Brain Energy and Membrane Metabolism in Glioblastoma following Chemoradiation
por: Grams, Astrid Ellen, et al.
Publicado: (2021)

An Inflammation Based Score Can Optimize the Selection of Patients with Advanced Cancer Considered for Early Phase Clinical Trials
por: Pinato, David J., et al.
Publicado: (2014)

NEOSCOPE: A randomised phase II study of induction chemotherapy followed by oxaliplatin/capecitabine or carboplatin/paclitaxel based pre-operative chemoradiation for resectable oesophageal adenocarcinoma
por: Mukherjee, Somnath, et al.
Publicado: (2017)

A predictive model for advanced oropharyngeal cancer patients treated with chemoradiation
por: Lo, Wu-Chia, et al.
Publicado: (2022)

Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2-UDP glucuronosyltransferase 1A metabolic axis activation
por: Hao, Qian, et al.
Publicado: (2020)

NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma
por: Mukherjee, Somnath, et al.
Publicado: (2015)

ERCC overexpression associated with a poor response of cT4b colorectal cancer with FOLFOX-based neoadjuvant concurrent chemoradiation
por: Huang, Ming-Yii, et al.
Publicado: (2020)

Adjuvant chemotherapy for colorectal cancer
por: Maughan, T S
Publicado: (2001)

Concurrent Chemoradiation for Vaginal Cancer
por: Miyamoto, David T., et al.
Publicado: (2013)

Cost‐effectiveness of chemoradiation followed by esophagectomy versus chemoradiation alone in squamous cell carcinoma of the esophagus
por: Salcedo, Jonathan, et al.
Publicado: (2019)

Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
por: Habermehl, Daniel, et al.
Publicado: (2013)

Potential of Proton Therapy to Reduce Acute Hematologic Toxicity in Concurrent Chemoradiation Therapy for Esophageal Cancer
por: Warren, Samantha, et al.
Publicado: (2017)

Response of FDG avid pelvic bone marrow to concurrent chemoradiation for anal cancer
por: Robinson, Maxwell, et al.
Publicado: (2020)

Radiobiological Determination of Dose Escalation and Normal Tissue Toxicity in Definitive Chemoradiation Therapy for Esophageal Cancer()
por: Warren, Samantha, et al.
Publicado: (2014)

Pseudomembranous colitis within radiotherapy field following concurrent chemoradiation therapy: a case report
por: Shen, Bing-Jie, et al.
Publicado: (2013)

The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives
por: Panieri, Emiliano, et al.
Publicado: (2020)

Standard chemoradiation versus intensity-modulated chemoradiation: a quality of life assessment in oropharyngeal cancer patients
por: Mowry, Sarah E., et al.
Publicado: (2009)

Survival After Induction Chemotherapy and Chemoradiation Versus Chemoradiation and Adjuvant Chemotherapy for Locally Advanced Rectal Cancer
por: Kim, Jin K, et al.
Publicado: (2022)

NRF2 as an Emerging Therapeutic Target
por: Copple, Ian M., et al.
Publicado: (2017)

Health-Related Quality of Life in SCALOP, a Randomized Phase 2 Trial Comparing Chemoradiation Therapy Regimens in Locally Advanced Pancreatic Cancer
por: Hurt, Christopher N., et al.
Publicado: (2015)

Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway
por: Zhu, Jin-Feng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pfs130icogvk71fvbficg7tds7