Cargando…

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis

The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved among mammals, with crucial roles in regulating embryonic development as well as in cancer initiation and progression. The GLI transcription factors (GLI1, GLI2, and GLI3) are effectors of the Hh pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chai, Jian Yi, Sugumar, Vaisnevee, Alshawsh, Mohammed Abdullah, Wong, Won Fen, Arya, Aditya, Chong, Pei Pei, Looi, Chung Yeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466551/ https://www.ncbi.nlm.nih.gov/pubmed/34572373 http://dx.doi.org/10.3390/biomedicines9091188

Ejemplares similares

Defining the Role of GLI/Hedgehog Signaling in Chemoresistance: Implications in Therapeutic Approaches
por: Chai, Jian Yi, et al.
Publicado: (2021)

Current Development of Chemical Penetration Enhancers for Transdermal Insulin Delivery
por: Sugumar, Vaisnevee, et al.
Publicado: (2023)

A Comprehensive Review of the Evolution of Insulin Development and Its Delivery Method
por: Sugumar, Vaisnevee, et al.
Publicado: (2022)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
por: Zhang, Jie, et al.
Publicado: (2021)

Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity
por: Peluso, Marisa O., et al.
Publicado: (2014)

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5
por: Chong, Yong Chun, et al.
Publicado: (2015)

Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
por: Jia, Jianhang, et al.
Publicado: (2022)

Roughing up Smoothened: chemical modulators of Hedgehog signaling
por: King, Randall W
Publicado: (2002)

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
por: Nedelcu, Daniel, et al.
Publicado: (2013)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
por: Marada, Suresh, et al.
Publicado: (2016)

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
por: Gonnissen, Annelies, et al.
Publicado: (2015)

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
por: Qi, Xiaofeng, et al.
Publicado: (2020)

Identification of a potent antagonist of smoothened in hedgehog signaling
por: Fan, Junwan, et al.
Publicado: (2021)

A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy
por: Fan, Junwan, et al.
Publicado: (2022)

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits
por: Arveseth, Corvin D., et al.
Publicado: (2021)

Endothelial Smoothened-dependent Hedgehog Signaling is Not Required for Sonic Hedgehog Induced Angiogenesis or Ischemic Tissue Repair
por: Gupta, Rajesh, et al.
Publicado: (2018)

Hedgehog pathway as a drug target: Smoothened inhibitors in development
por: Lin, Tara L, et al.
Publicado: (2012)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
por: Nachtergaele, Sigrid, et al.
Publicado: (2013)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
por: Zhao, Zhonghua, et al.
Publicado: (2016)

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling
por: Desai, Paurav B., et al.
Publicado: (2020)

Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma
por: Pereira, Victor, et al.
Publicado: (2021)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
por: Chahal, Kirti Kandhwal, et al.
Publicado: (2019)

A G protein functions immediately downstream of Smoothened in Hedgehog signaling
por: Ogden, Stacey K., et al.
Publicado: (2008)

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
por: Rana, Rajashree, et al.
Publicado: (2013)

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
por: Rimkus, Tadas K., et al.
Publicado: (2016)

SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling
por: Zhang, Jie, et al.
Publicado: (2017)

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
por: Loh, Chin-Yap, et al.
Publicado: (2019)

Transcriptomic and Genomic Approaches for Unravelling Candida albicans Biofilm Formation and Drug Resistance—An Update
por: Chong, Pei Pei, et al.
Publicado: (2018)

Corrigendum: The Microbiome and Irritable Bowel Syndrome – A Review on the Pathophysiology, Current Research and Future Therapy
por: Chong, Pei Pei, et al.
Publicado: (2019)

The Microbiome and Irritable Bowel Syndrome – A Review on the Pathophysiology, Current Research and Future Therapy
por: Chong, Pei Pei, et al.
Publicado: (2019)

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila
por: Li, Shuang, et al.
Publicado: (2012)

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
por: Frank-Kamenetsky, Maria, et al.
Publicado: (2002)

Hrs Promotes Ubiquitination and Mediates Endosomal Trafficking of Smoothened in Drosophila Hedgehog Signaling
por: Fan, Junkai, et al.
Publicado: (2013)

NrCAM modulates sonic hedgehog signalling by controlling smoothened translocation in the cilium
por: Basu, B, et al.
Publicado: (2015)

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation
por: Jung, Bomi, et al.
Publicado: (2016)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
por: Luchetti, Giovanni, et al.
Publicado: (2016)

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma
por: Dunatov Huljev, Ana, et al.
Publicado: (2023)

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges
por: Loh, Chin-Yap, et al.
Publicado: (2019)

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance
por: Gruber, Wolfgang, et al.
Publicado: (2016)

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
por: Jung, Bomi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_u26osnji0fdoae4u1dm8ded1e7