Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However, the overproduction of lactic acid and its inefficiency in cancer therapy limit its application. Here, we demonstrate the synergistic effects of the lactate/GPR81 blockade (3-hydroxy-butyrate, 3-OBA) and metfor...

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Detalles Bibliográficos
Autores principales: Chen, Shaomeng, Zhou, Xiuman, Yang, Xin, Li, Wanqiong, Li, Shuzhen, Hu, Zheng, Ling, Chen, Shi, Ranran, Liu, Juan, Chen, Guanyu, Song, Nazi, Jiang, Xianxing, Sui, Xinghua, Gao, Yanfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466555/
https://www.ncbi.nlm.nih.gov/pubmed/34572586
http://dx.doi.org/10.3390/biom11091373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466555/
https://www.ncbi.nlm.nih.gov/pubmed/34572586
http://dx.doi.org/10.3390/biom11091373

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