Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells

BACKGROUND: Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcription factor. Mutations in BMPR2 trafficking proteins leads to overactive BMP signa...

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Detalles Bibliográficos
Autores principales: Mondal, Arindam, NeMoyer, Rachel, Vora, Mehul, Napoli, Logan, Syed, Zoya, Langenfeld, Elaine, Jia, Dongxuan, Peng, Youyi, Gilleran, John, Roberge, Jacques, Rongo, Christopher, Jabbour, Salma K., Langenfeld, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466694/
https://www.ncbi.nlm.nih.gov/pubmed/34563224
http://dx.doi.org/10.1186/s12964-021-00743-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466694/
https://www.ncbi.nlm.nih.gov/pubmed/34563224
http://dx.doi.org/10.1186/s12964-021-00743-w

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