Active-site engineering of ω-transaminase from Ochrobactrum anthropi for preparation of L-2-aminobutyric acid

BACKGROUND: The unnatural amino acid, L-2-aminobutyric acid (L-ABA) is an essential chiral building block for various pharmaceutical drugs, such as the antiepileptic drug levetiracetam and the antituberculosis drug ethambutol. The present study aims at obtaining variants of ω-transaminase from Ochro...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zhiwei, Liu, Yang, Zhao, Jing, Li, Wenqiang, Hu, Ruiwen, Li, Xia, Li, Aitao, Wang, Yaping, Ma, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466713/
https://www.ncbi.nlm.nih.gov/pubmed/34563172
http://dx.doi.org/10.1186/s12896-021-00713-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466713/
https://www.ncbi.nlm.nih.gov/pubmed/34563172
http://dx.doi.org/10.1186/s12896-021-00713-7

Ejemplares similares