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Active-site engineering of ω-transaminase from Ochrobactrum anthropi for preparation of L-2-aminobutyric acid

BACKGROUND: The unnatural amino acid, L-2-aminobutyric acid (L-ABA) is an essential chiral building block for various pharmaceutical drugs, such as the antiepileptic drug levetiracetam and the antituberculosis drug ethambutol. The present study aims at obtaining variants of ω-transaminase from Ochro...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhiwei, Liu, Yang, Zhao, Jing, Li, Wenqiang, Hu, Ruiwen, Li, Xia, Li, Aitao, Wang, Yaping, Ma, Lixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466713/ https://www.ncbi.nlm.nih.gov/pubmed/34563172 http://dx.doi.org/10.1186/s12896-021-00713-7

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