Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

BACKGROUND: During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microglia, and possibly other cell types. This model supports th...

Descripción completa

Detalles Bibliográficos
Autores principales: Papazian, Irini, Tsoukala, Eleni, Boutou, Athena, Karamita, Maria, Kambas, Konstantinos, Iliopoulou, Lida, Fischer, Roman, Kontermann, Roland E., Denis, Maria C., Kollias, George, Lassmann, Hans, Probert, Lesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466720/
https://www.ncbi.nlm.nih.gov/pubmed/34565380
http://dx.doi.org/10.1186/s12974-021-02200-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466720/
https://www.ncbi.nlm.nih.gov/pubmed/34565380
http://dx.doi.org/10.1186/s12974-021-02200-4

Ejemplares similares