Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

BACKGROUND: During inflammatory demyelination, TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF (solTNF), whereas TNFR2 mediates beneficial effects of transmembrane TNF (tmTNF) through oligodendroglia, microglia, and possibly other cell types. This model supports th...

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Detalles Bibliográficos
Autores principales: Papazian, Irini, Tsoukala, Eleni, Boutou, Athena, Karamita, Maria, Kambas, Konstantinos, Iliopoulou, Lida, Fischer, Roman, Kontermann, Roland E., Denis, Maria C., Kollias, George, Lassmann, Hans, Probert, Lesley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466720/
https://www.ncbi.nlm.nih.gov/pubmed/34565380
http://dx.doi.org/10.1186/s12974-021-02200-4

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