DNA Intercalators Inhibit Eukaryotic Ribosomal RNA Synthesis by Impairing the Initiation of Transcription

In eukaryotes, ribosome biogenesis is driven by the synthesis of the ribosomal RNA (rRNA) by RNA polymerase I (Pol-I) and is tightly linked to cell growth and proliferation. The 3D-structure of the rDNA promoter plays an important, yet not fully understood role in regulating rRNA synthesis. We hypot...

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Detalles Bibliográficos
Autores principales: Andrews, William J., Ray, Swagat, Panova, Tatiana, Engel, Christoph, Panov, Konstantin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466728/
https://www.ncbi.nlm.nih.gov/pubmed/34573394
http://dx.doi.org/10.3390/genes12091412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466728/
https://www.ncbi.nlm.nih.gov/pubmed/34573394
http://dx.doi.org/10.3390/genes12091412

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