Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis

Vicious cycles of chronic airway obstruction, lung infections with Pseudomonas aeruginosa, and neutrophil-dominated inflammation contribute to morbidity and mortality in cystic fibrosis (CF) patients. Rhesus theta defensin-1 (RTD-1) is an antimicrobial macrocyclic peptide with immunomodulatory prope...

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Detalles Bibliográficos
Autores principales: Dughbaj, Mansour A., Jayne, Jordanna G., Park, A Young J., Bensman, Timothy J., Algorri, Marquerita, Ouellette, Andre J., Selsted, Michael E., Beringer, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466744/
https://www.ncbi.nlm.nih.gov/pubmed/34572625
http://dx.doi.org/10.3390/antibiotics10091043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466744/
https://www.ncbi.nlm.nih.gov/pubmed/34572625
http://dx.doi.org/10.3390/antibiotics10091043

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