GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge Stylissa sp. Extends Its Therapeutic Potential for Noncommunicable Diseases

We report the first isolation of the alkaloid aaptamine from the Philippine marine sponge Stylissa sp. Aaptamine possessed weak antiproliferative activity against HCT116 colon cancer cells and inhibited the proteasome in vitro at 50 µM. These activities may be functionally linked. Due to its known,...

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Detalles Bibliográficos
Autores principales: Luyao, Harmie, Luesch, Hendrik, Uy, Mylene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466755/
https://www.ncbi.nlm.nih.gov/pubmed/34577088
http://dx.doi.org/10.3390/molecules26185618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466755/
https://www.ncbi.nlm.nih.gov/pubmed/34577088
http://dx.doi.org/10.3390/molecules26185618

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