Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson’s Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology

Accumulation of α-synuclein (α-syn) into Lewy bodies (LBs) and mitochondrial abnormalities are the two cardinal pathobiological features of Parkinson’s disease (PD), which are associated with the loss of dopaminergic neurons. Although α-syn accumulates in many different cellular and mouse models, th...

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Detalles Bibliográficos
Autores principales: Diao, Xiaojun, Wang, Fei, Becerra-Calixto, Andrea, Soto, Claudio, Mukherjee, Abhisek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467069/
https://www.ncbi.nlm.nih.gov/pubmed/34572052
http://dx.doi.org/10.3390/cells10092402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467069/
https://www.ncbi.nlm.nih.gov/pubmed/34572052
http://dx.doi.org/10.3390/cells10092402

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