Exploring the Role of L10 Loop in New Delhi Metallo-β-lactamase (NDM-1): Kinetic and Dynamic Studies

Four NDM-1 mutants (L218T, L221T, L269H and L221T/Y229W) were generated in order to investigate the role of leucines positioned in L10 loop. A detailed kinetic analysis stated that these amino acid substitutions modified the hydrolytic profile of NDM-1 against some β-lactams. Significant reduction o...

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Detalles Bibliográficos
Autores principales: Piccirilli, Alessandra, Criscuolo, Emanuele, Brisdelli, Fabrizia, Mercuri, Paola Sandra, Cherubini, Sabrina, De Sciscio, Maria Laura, Maccarrone, Mauro, Galleni, Moreno, Amicosante, Gianfranco, Perilli, Mariagrazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467308/
https://www.ncbi.nlm.nih.gov/pubmed/34576958
http://dx.doi.org/10.3390/molecules26185489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467308/
https://www.ncbi.nlm.nih.gov/pubmed/34576958
http://dx.doi.org/10.3390/molecules26185489

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