Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation

Protein degradation by the Ubiquitin-Proteasome System is one of the main mechanisms of the regulation of cellular proteostasis, and the E3 ligases are the key effectors for the protein recognition and degradation. Many E3 ligases have key roles in cell cycle regulation, acting as checkpoints and ch...

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Detalles Bibliográficos
Autores principales: Márquez-Cantudo, Laura, Ramos, Ana, Coderch, Claire, de Pascual-Teresa, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467390/
https://www.ncbi.nlm.nih.gov/pubmed/34577077
http://dx.doi.org/10.3390/molecules26185606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467390/
https://www.ncbi.nlm.nih.gov/pubmed/34577077
http://dx.doi.org/10.3390/molecules26185606

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