An Influence of Modification with Phosphoryl Guanidine Combined with a 2′-O-Methyl or 2′-Fluoro Group on the Small-Interfering-RNA Effect

Small interfering RNA (siRNA) is the most important tool for the manipulation of mRNA expression and needs protection from intracellular nucleases when delivered into the cell. In this work, we examined the effects of siRNA modification with the phosphoryl guanidine (PG) group, which, as shown earli...

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Detalles Bibliográficos
Autores principales: Pavlova, Anna S., Yakovleva, Kristina I., Epanchitseva, Anna V., Kupryushkin, Maxim S., Pyshnaya, Inna A., Pyshnyi, Dmitrii V., Ryabchikova, Elena I., Dovydenko, Ilya S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467447/
https://www.ncbi.nlm.nih.gov/pubmed/34575949
http://dx.doi.org/10.3390/ijms22189784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467447/
https://www.ncbi.nlm.nih.gov/pubmed/34575949
http://dx.doi.org/10.3390/ijms22189784

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