The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants

Fucosylated glycosaminoglycan (FG) from sea cucumber is a potent anticoagulant by inhibiting intrinsic coagulation tenase (iXase). However, high-molecular-weight FGs can activate platelets and plasma contact system, and induce hypotension in rats, which limits its application. Herein, we found that...

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Detalles Bibliográficos
Autores principales: Lin, Lisha, Li, Sujuan, Gao, Na, Wang, Weili, Zhang, Taocui, Yang, Lian, Yang, Xingzhi, Luo, Dan, Ji, Xu, Zhao, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467514/
https://www.ncbi.nlm.nih.gov/pubmed/34564149
http://dx.doi.org/10.3390/md19090487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467514/
https://www.ncbi.nlm.nih.gov/pubmed/34564149
http://dx.doi.org/10.3390/md19090487

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