Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology

Ubiquitin Specific Protease-13 (USP13) promotes protein de-ubiquitination and is poorly understood in neurodegeneration. USP13 is upregulated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), and USP13 knockdown via shRNA reduces neurotoxic proteins and increases proteasome activity in model...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoguang, Balaraman, Kaluvu, Lynch, Ciarán C., Hebron, Michaeline, Wolf, Christian, Moussa, Charbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467576/
https://www.ncbi.nlm.nih.gov/pubmed/34564439
http://dx.doi.org/10.3390/metabo11090622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467576/
https://www.ncbi.nlm.nih.gov/pubmed/34564439
http://dx.doi.org/10.3390/metabo11090622

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