Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy

SIMPLE SUMMARY: The formats of bispecific antibody have been investigated for many years to enhance the stability of the structure and anti-tumor efficacy. One of the formats combining two Fabs at their C termini provides unmodified variable region and comparable activity to other fragment-based bis...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Xuefei, Liu, Wenhui, Jin, Shijie, Zhao, Wenbin, Xu, Yingchun, Zhou, Zhan, Chen, Shuqing, Pan, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467688/
https://www.ncbi.nlm.nih.gov/pubmed/34572769
http://dx.doi.org/10.3390/cancers13184540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467688/
https://www.ncbi.nlm.nih.gov/pubmed/34572769
http://dx.doi.org/10.3390/cancers13184540

Ejemplares similares