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Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy

SIMPLE SUMMARY: The formats of bispecific antibody have been investigated for many years to enhance the stability of the structure and anti-tumor efficacy. One of the formats combining two Fabs at their C termini provides unmodified variable region and comparable activity to other fragment-based bis...

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Detalles Bibliográficos
Autores principales:	Bai, Xuefei, Liu, Wenhui, Jin, Shijie, Zhao, Wenbin, Xu, Yingchun, Zhou, Zhan, Chen, Shuqing, Pan, Liqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467688/ https://www.ncbi.nlm.nih.gov/pubmed/34572769 http://dx.doi.org/10.3390/cancers13184540

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