The Genetic Architecture of a Congenital Heart Defect Is Related to Its Fitness Cost

In newborns, severe congenital heart defects are rarer than mild ones. This epidemiological relationship between heart defect severity and incidence lacks explanation. Here, an analysis of ~10,000 Nkx2-5(+/−) mice from two inbred strain crosses illustrates the fundamental role of epistasis. Modifier...

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Detalles Bibliográficos
Autores principales: Akhirome, Ehiole, Regmi, Suk D., Magnan, Rachel A., Ugwu, Nelson, Qin, Yidan, Schulkey, Claire E., Cheverud, James M., Jay, Patrick Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467714/
https://www.ncbi.nlm.nih.gov/pubmed/34573350
http://dx.doi.org/10.3390/genes12091368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467714/
https://www.ncbi.nlm.nih.gov/pubmed/34573350
http://dx.doi.org/10.3390/genes12091368

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