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The Genetic Architecture of a Congenital Heart Defect Is Related to Its Fitness Cost
In newborns, severe congenital heart defects are rarer than mild ones. This epidemiological relationship between heart defect severity and incidence lacks explanation. Here, an analysis of ~10,000 Nkx2-5(+/−) mice from two inbred strain crosses illustrates the fundamental role of epistasis. Modifier...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467714/ https://www.ncbi.nlm.nih.gov/pubmed/34573350 http://dx.doi.org/10.3390/genes12091368 |