Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives

Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists, μ-agonists are the only ones used in therapy...

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Detalles Bibliográficos
Autores principales: Piras, Sandra, Murineddu, Gabriele, Loriga, Giovanni, Carta, Antonio, Battistello, Enrica, Merighi, Stefania, Gessi, Stefania, Corona, Paola, Asproni, Battistina, Ibba, Roberta, Temml, Veronika, Schuster, Daniela, Pinna, Gérard Aimè
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467848/
https://www.ncbi.nlm.nih.gov/pubmed/34576918
http://dx.doi.org/10.3390/molecules26185448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467848/
https://www.ncbi.nlm.nih.gov/pubmed/34576918
http://dx.doi.org/10.3390/molecules26185448

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