Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective

The cytotoxic necrotizing factor 1 (CNF1) toxin from uropathogenic Escherichia coli constitutively activates Rho GTPases by catalyzing the deamidation of a critical glutamine residue located in the switch II (SWII). In crystallographic structures of the CNF1 catalytic domain (CNF1(CD)), surface-expo...

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Detalles Bibliográficos
Autores principales: Paillares, Eléa, Marechal, Maud, Swistak, Léa, Tsoumtsa Meda, Landry, Lemichez, Emmanuel, Malliavin, Thérèse E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467853/
https://www.ncbi.nlm.nih.gov/pubmed/34576292
http://dx.doi.org/10.3390/ijms221810129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467853/
https://www.ncbi.nlm.nih.gov/pubmed/34576292
http://dx.doi.org/10.3390/ijms221810129

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