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Significance of NPM1 Gene Mutations in AML
The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467861/ https://www.ncbi.nlm.nih.gov/pubmed/34576201 http://dx.doi.org/10.3390/ijms221810040 |
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author | Hindley, Andrew Catherwood, Mark Alexander McMullin, Mary Frances Mills, Ken I. |
author_facet | Hindley, Andrew Catherwood, Mark Alexander McMullin, Mary Frances Mills, Ken I. |
author_sort | Hindley, Andrew |
collection | PubMed |
description | The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of NPM1 mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting NPM1 mutated AML are considered. |
format | Online Article Text |
id | pubmed-8467861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84678612021-09-27 Significance of NPM1 Gene Mutations in AML Hindley, Andrew Catherwood, Mark Alexander McMullin, Mary Frances Mills, Ken I. Int J Mol Sci Review The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment options available to patients will also be reviewed along with current guidelines recommending the rapid return of NPM1 mutational screening results and the importance of employing a suitable laboratory assay to achieve this. Finally, future developments in the field including research into new therapies targeting NPM1 mutated AML are considered. MDPI 2021-09-17 /pmc/articles/PMC8467861/ /pubmed/34576201 http://dx.doi.org/10.3390/ijms221810040 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hindley, Andrew Catherwood, Mark Alexander McMullin, Mary Frances Mills, Ken I. Significance of NPM1 Gene Mutations in AML |
title | Significance of NPM1 Gene Mutations in AML |
title_full | Significance of NPM1 Gene Mutations in AML |
title_fullStr | Significance of NPM1 Gene Mutations in AML |
title_full_unstemmed | Significance of NPM1 Gene Mutations in AML |
title_short | Significance of NPM1 Gene Mutations in AML |
title_sort | significance of npm1 gene mutations in aml |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467861/ https://www.ncbi.nlm.nih.gov/pubmed/34576201 http://dx.doi.org/10.3390/ijms221810040 |
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