Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells

Osteoarthritis is a degenerative disease, often resulting in chronic joint pain and commonly affecting elderly people. Current treatments with anti-inflammatory drugs are palliative, making the discovery of new treatments necessary. The inhibition of matrix metalloproteinase MMP-13 is a validated st...

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Detalles Bibliográficos
Autores principales: Zapico, Jose Maria, Acosta, Lourdes, Pastor, Miryam, Rangasamy, Loganathan, Marquez-Cantudo, Laura, Coderch, Claire, Ortin, Irene, Nicolau-Sanus, Maria, Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio, Majali-Martinez, Alejandro, Ramos, Pilar, de Pascual-Teresa, Beatriz, Ramos, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467962/
https://www.ncbi.nlm.nih.gov/pubmed/34576138
http://dx.doi.org/10.3390/ijms22189976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467962/
https://www.ncbi.nlm.nih.gov/pubmed/34576138
http://dx.doi.org/10.3390/ijms22189976

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