Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surfactants, and cosurfactants were screened for their...

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Detalles Bibliográficos
Autores principales: Buya, Aristote B., Terrasi, Romano, Mbinze, Jérémie K., Muccioli, Giulio G., Beloqui, Ana, Memvanga, Patrick B., Préat, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468394/
https://www.ncbi.nlm.nih.gov/pubmed/34575467
http://dx.doi.org/10.3390/pharmaceutics13091388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468394/
https://www.ncbi.nlm.nih.gov/pubmed/34575467
http://dx.doi.org/10.3390/pharmaceutics13091388

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