Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism

Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor. Wide inter-subject variability observed in oxycodone efficacy could be explained by polymorphi...

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Detalles Bibliográficos
Autores principales: Deodhar, Malavika, Turgeon, Jacques, Michaud, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468517/
https://www.ncbi.nlm.nih.gov/pubmed/34575542
http://dx.doi.org/10.3390/pharmaceutics13091466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468517/
https://www.ncbi.nlm.nih.gov/pubmed/34575542
http://dx.doi.org/10.3390/pharmaceutics13091466

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