Tau N-Terminal Inserts Regulate Tau Liquid-Liquid Phase Separation and Condensates Maturation in a Neuronal Cell Model

The microtubule-associated protein tau can undergo liquid–liquid phase separation (LLPS) to form membraneless condensates in neurons, yet the underlying molecular mechanisms and functions of tau LLPS and tau droplets remain to be elucidated. The human brain contains mainly 6 tau isoforms with differ...

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Detalles Bibliográficos
Autores principales: Wu, Chengchen, Zhao, Junyi, Wu, Qiuping, Tan, Qiulong, Liu, Qiong, Xiao, Shifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468574/
https://www.ncbi.nlm.nih.gov/pubmed/34575888
http://dx.doi.org/10.3390/ijms22189728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468574/
https://www.ncbi.nlm.nih.gov/pubmed/34575888
http://dx.doi.org/10.3390/ijms22189728

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