Quest for the Molecular Basis of Improved Selective Toxicity of All-Trans Isomers of Aromatic Heptaene Macrolide Antifungal Antibiotics

Three aromatic heptaene macrolide antifungal antibiotics, Candicidin D, Partricin A (Gedamycin) and Partricin B (Vacidin) were subjected to controlled cis-trans → all trans photochemical isomerization. The obtained all-trans isomers demonstrated substantially improved in vitro selective toxicity in...

Descripción completa

Detalles Bibliográficos
Autores principales: Borzyszkowska-Bukowska, Julia, Górska, Justyna, Szczeblewski, Paweł, Laskowski, Tomasz, Gabriel, Iwona, Jurasz, Jakub, Kozłowska-Tylingo, Katarzyna, Szweda, Piotr, Milewski, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468583/
https://www.ncbi.nlm.nih.gov/pubmed/34576271
http://dx.doi.org/10.3390/ijms221810108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8468583/
https://www.ncbi.nlm.nih.gov/pubmed/34576271
http://dx.doi.org/10.3390/ijms221810108

Ejemplares similares